Tuesday, 23rd November ESA-SRB-ANZBMS 2021

A panel discussion between international and local experts on managing adult patients with endocrine failure as a result of childhood cancer treatments 

Chair - Professor Margaret Zacharin, Murdoch Children's Research Institute, The Royal Children's Hospital

Speaker - Professor Laurie Cohen MD, Associate Professor of Paediatrics, Harvard Medical School

The conference acknowledges the support of:

• Late endocrine effects of childhood cancers and the management into adulthood - Laurie Cohen

• Dysregulation of the Male Gonadal Axis due to Energy Deficit - Mathis Grossmann
• Optimizing Performance in Female Athletes: A Spotlight on Hormonal Contraception  - Clare Minahan
• Exercise and bone turnover markers: implications for health - Itamar Levinger
• Detection of Designer Steroids Using Androgen Bioassays  - Alison K Heather

The conference acknowledges the support of:

• SPINT2 expression in pregnancies complicated by placental insufficiency - Ciara Murphy
• Reduced progesterone signalling in the peri-conception phase programs impaired immune tolerance in adult female offspring - Stacey J. Savin
• Assessment of the tocolytic nifedipine in pre-clinical primary models of preterm birth - Bridget Arman
• Epsilon tubulin is required for fertility in male mice and has essential roles in meiosis and spermatid remodelling - Gemma Stathatos
• Comparative analysis of a newly discovered human endometrial receptivity marker in rhesus macaques and mice - Bothidah Thach
• Shifting the paradigm of sperm maturation; global proteomic profiling of epididymal sperm - David A Skerrett-Byrne

The conference acknowledges the support of:

12:10 PM Panel Discussion

• Investigating the Effects of Gender-Affirming Hormone Therapy on Bone Using Pre-Clinical Models - Rachel Davey
• Gender affirming hormonal therapies for trans and gender diverse adolescents  - Michele O'Connell
• Psychological Challenges for Transgender Patients - Emerson Osterberg
• Clinical Aspects of Bone Health in the Transgender Population - Ada S Cheung
• Being transgender: a community member’s perspective - Clare Headland

• Regulatory T cells facilitate maternal vascular adaptations to pregnancy - Alison Care
• Oocyte-cumulus cell bidirectional communication impacts oocyte quality - Dulama Richani
• Oral Metformin: the first disease modifying drug for preeclampsia  - Stephen Tong
• Omega-3 Supplementation to Prevent Preterm Birth - Craig Pennell

• Targeting N-cadherin during ovulation- a non-hormonal contraceptive - Alaknanda Emery
• Ovarian cell metabolism at ovulation is correlated with oocyte competence and impacted by obesity and aging - Atsushi Morimoto
• Modulation of the oocyte epigenome by a mitochondrial fission protein - Deepak Adhikari
• Cyclin A2 supports faithful chromosome segregation in the oocyte to embryo transition - Qing-hua Zhang
• PRC2 establishes H3K27me3 at developmental genes in growing oocytes and regulates offspring development rate - Ellen Jarred
• Checkpoint inhibitor immunotherapy diminishes oocyte number and quality: consequences for fertility of female cancer survivors - Lauren R Alesi
• Molecular modelling using a PCOS mouse model in combination with androgen receptor knockout mouse models (ARKO) to unravel PCOS pathogenesis - Valentina Rodriguez Paris
• Progesterone receptor regulation of ovulation via respiration, glycolysis, fatty-acid oxidation and cell-specific signaling - Kirsten Smith

https://spatial.chat/s/esasrbanzbms2021

https://spatial.chat/s/esasrbanzbms2021

The conference acknowledges the support of:

• Diverse Roles of the Androgen Receptor in Breast and Prostate Cancer - Wayne D Tilley

The conference acknowledges the support of:

• Clinical factors affecting insulin dose requirements during treatment of prednisolone-induced hyperglycaemia - Angela Xun-Nan Chen
• An algorithm to guide radioactive iodine treatment. - Ayanthi Wijewardene
• Corticosteroid-binding globulin deficiency independently predicts mortality and is associated with norepinephrine requirements in septic shock. - Emily J Meyer
• Surveillance improves outcomes for SDHB mutation carriers: a multi-centre study - Dahlia Davidoff
• Effects of estradiol on bone density and fat mass in men undergoing androgen deprivation therapy for prostate cancer: a randomised placebo-controlled trial - Nicholas Russell
• Increasing the detection of primary aldosteronism: a prospective study in Australian primary care - Renata Libianto
• Reproductive and metabolic health of young men conceived using ICSI - Sarah Catford

The conference acknowledges the support of:

• Type 2 diabetes, fracture risk and mortality in two longitudinal population-based studies: Dubbo Osteoporosis Epidemiology Study (DOES) and the Canadian Multicentre osteoporosis study (CaMos) - Nithin Kolanu
• Estradiol preserves endocortical and trabecular bone in an adolescent male-to-female mouse model of gender affirming hormone therapy. - Tian Nie
• Elucidating the genetic effect of vitamin D on mesenchymal stem cells differentiation and function in vitro - Ahmed Al Saedi
• Bone Microarchitecture and Estimated Failure Load are Deteriorated Whether Patients with Chronic Kidney Disease have Normal Bone Mineral Density, Osteopenia or Osteoporosis - Ali Ghasem-Zadeh
• Osteocalcin, Muscle Function and 15-year Falls-related Hospitalizations in Older Women: The Perth Longitudinal Study of Ageing Women - Cassandra Smith
• Fracture risk and use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers - Kara B Anderson
• Proteomics of secretory lysosomes unmasks new regulators of osteoclast function and skeletal bone mass   - Amy B P Ribet
• Characterising human skeletal stem cell populations in different skeletal compartments - Ye Cao

https://spatial.chat/s/esasrbanzbms2021

The conference acknowledges the support of:

• Endothelial protein C receptor (EPCR) is deranged in preeclampsia  - Faith Andres
• Alterations in placental endothelial and perivascular heterogeneity could contribute to the pathophysiology of fetal growth restriction - Anna L Boss
• Regulatory T cells modulate uterine natural killer cells to promote spiral artery remodelling in mice - Shanna L Hosking
• A potential role for the (pro)renin receptor and soluble (pro)renin receptor in the pathogenesis of choriocarcinoma - Saije K. Morosin

The conference acknowledges the support of:

• Malate dehydrogenase 1B is a testis enriched energy protein required for sperm function and male fertility - Tianpengcheng (Amy) Luan
• Field fertility of a novel bovine sperm storage medium following seven days of ambient temperature storage - Erin K Klein
• Fabrication on the microscale: two-photon polymerised device for microinjection - Suliman H Yagoub
• Cripto promotes pluripotency and malignancy of the male germline in mice - Guillaume Burnet

• An ex vivo approach to understanding sex-specific differences in placental androgen signalling in the presence and absence of inflammation - Ashley S Meakin
• Analysis of novel glucocorticoid receptor agonists as potential treatments for preterm birth - Rutu S Dhavan
• Does Capsaicin "Beige" Human White Fat that has been Transplanted into Mice and Exhibit Improvements in Mouse Metabolism? - Sarah Davis
• Concurrent Betaine Administration Enhances the Benefits of Exercise in a Mouse Model of Diet-Induced Obesity - Josephine Yu
• Characterization of 11bhsd1l a novel member of the 11bhydroxysteroid dehydrogenase enzyme family - Elias Valbe
• Glucocorticoid regulation of primary ciliogenesis in the developing mouse kidney - Jianshen Lao
• Oxidative stress promotes glucocorticoid-induced mineralocorticoid receptor (MR) transcriptional activity in cardiomyocytes - Monica Kanki
• Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes - Mitchell A Sullivan

• Production of bone matrix in recovery from bone loss during breast-feeding is independent of 1,25-dihydroxy-Vitamin D₃ (calcitriol) - Narelle E McGregor
• Bisphosphonate drugs have effects outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages in lung - Emma K Fletcher
• Osteoblast-derived egfl6 couples angiogenesis to osteogenesis during bone repair - Kai Chen
• Combination treatment with undercarboxylated osteocalcin and ibandronate protects against hind-limb immobilisation-induced muscle wasting - Xuzhu Lin
• PI3K signaling in Dmp1-expressing cells drives periosteal bone formation and bone strength - Natalie KY Wee
• Targeting osteocytes: quantifying their cellular uptake with a high throughput internalisation assay - Niloufar Ansari
• Unsuppressed STAT3 signaling in osteocytes exaggerates cortical bone response to mechanical load - Emma C Walker

The conference acknowledges the support of:

• Bone Quality Assessment in Health and Disease - Björn Busse

The conference acknowledges the support of:

• Exploring the mechanisms underlying the metabolic improvements following bariatric surgery - Aneta Stefanidis

The conference acknowledges the support of:

• Perturbed BMP signalling and denervation promote muscle wasting in cancer cachexia - Adam Hagg

The conference acknowledges the support of:

• Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT - Mark Ng Tang Fui

The conference acknowledges the support of:

• New Diagnostic and Therapeutic Options in Vasopressin-Dependent Fluid Disorders - Mirjam Christ-Crain

• Gene Therapy Approaches to Rapidly Manipulate Testis Function  - Lee B Smith
• Genomics and High Throughput Screening Analysis of Progesterone Receptor Action for Discovering Selective Molecular Targets for Blocking Ovulation - Darryl Russell
• Using epigenetics and cell of origin analysis as diagnostics for azoospermia - Timothy Jenkins
• Mitochondria, Maternal Inheritance and Implications for Male Reproductive Health  - Damian k Dowling

• Discovery of a key regulator of endometrial receptivity for embryo implantation - Sophea Heng
• Defining the heterogeneity and function of macrophages during endometrial tissue repair - Douglas A Gibson
• Puma knockout protects the uterus from radiotherapy-mediated damage: implications for fertility preservation for female cancer survivors - Meaghan Griffiths
• Detrimental actions of obesity-associated Advanced Glycation Endproducts on endometrial epithelial cell proliferation are alleviated by antioxidants and are donor-dependent in human endometrial organoids - Jennifer C Hutchison
• A promising future for the novel zinc IUD now confirmed long acting and reversible in rats - Kirsten Shankie-Williams
• Heterogeneity in the distribution of smooth muscle actin, collagen fibres and immune cells associated with superficial peritoneal endometriotic lesions - Jane Girling
• A novel mouse model of retrograde menstruation for the study of endometriosis - Emanuele Pelosi
• Jagged1 regulates endometrial receptivity in both humans and mice - Wei Zhou