Oral Virtual Presentation (Virtual only) ESA-SRB-ANZBMS 2021

Corticosteroid-binding globulin deficiency independently predicts mortality and is associated with norepinephrine requirements in septic shock. (#138)

Emily J Meyer 1 2 3 , Marni A Nenke 1 2 4 , Marianne Chapman 5 , Wayne Rankin 1 2 6 , Louise L Rushworth 7 , David J Torpy 1 2
  1. Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  2. Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia
  3. Department of Endocrinology and Diabetes, The Queen Elizabeth Hospital, Woodville, SA , Australia
  4. Department of Endocrinology and Diabetes, The Queen Elizabeth Hospital, Adelaide, SA, Australia
  5. Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  6. Chemical Pathology Directorate, SA Pathology, Adelaide, SA, Australia
  7. School of Medicine, The University of Notre Dame, Sydney, New South Wales, Australia
Publish consent withheld
  1. Venkatesh B, Finfer S, Cohen J, et al. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. N Engl J Med. 2018;378:797-808.
  2. Annane D, Renault A, Brun-Buisson C, et al. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. N Engl J Med. 2018;378:809-818.
  3. Meyer EJ, Torpy DJ, Chernykh A, et al. Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid-binding globulin. Protein Sci. 2020;29:2495-2509.
  4. Nenke MA, Rankin W, Chapman MJ, et al. Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications. Clin Endocrinol (Oxf). 2015;82:801-807.
  5. Meyer EJ, Nenke MA, Rankin W, et al. Total and high-affinity corticosteroid-binding globulin depletion in septic shock is associated with mortality. Clin Endocrinol (Oxf). 2019;90:232-240.